General Information

  • ID:  hor004890
  • Uniprot ID:  P42994
  • Protein name:  Glumitocin
  • Gene name:  NA
  • Organism:  Raja clavata (Thornback ray)
  • Family:  Vasopressin/oxytocin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Raja (genus), Rajidae (family), Rajiformes (order), Batoidea (superorder), Elasmobranchii (subclass), Chondrichthyes (class), Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity; GO:0005185 neurohypophyseal hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  CYISNCPQG
  • Length:  9
  • Propeptide:  CYISNCPQG
  • Signal peptide:  NA
  • Modification:  T9 Glycine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Antidiuretic hormone
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  1-6
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004890_AF2.pdbhor004890_ESM.pdb

Physical Information

Mass: 112699 Formula: C40H61N11O14S2
Absent amino acids: ADEFHKLMRTVW Common amino acids: C
pI: 5.81 Basic residues: 0
Polar residues: 6 Hydrophobic residues: 1
Hydrophobicity: -17.78 Boman Index: -730
Half-Life: 1.2 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 43.33
Instability Index: 4848.89 Extinction Coefficient cystines: 1615
Absorbance 280nm: 201.88

Literature

  • PubMed ID:  5880565
  • Title:  Phylogeny of neurophyophyseal peptides: isolation of a new hormone, glumitocin (Ser 4-Gln 8-ocytocin) present in a cartilaginous fish, the ray (Raia clavata).